Salivary caffeine metabolic ratio in alcohol-dependent subjects

  title={Salivary caffeine metabolic ratio in alcohol-dependent subjects},
  author={Veerapol Kukongviriyapan and Laddawan Senggunprai and Auemduan Prawan and Danu Gaysornsiri and Upa Kukongviriyapan and Jareerat Aiemsa-ard},
  journal={European Journal of Clinical Pharmacology},
To determine whether caffeine (CA) clearance and salivary paraxanthine (PX)/CA ratio were altered in alcohol-dependent subjects and also whether salivary PX/CA ratio was affected by arylamine-N-acetylation 2 (NAT-2) genotypes. Of 30 male individuals recruited in assessing PX/CA ratio and CA clearance by ingestion of CA, 13 were healthy control, 10 were alcohol-dependent subjects with abnormal liver function tests and 7 were alcohol-dependent subjects with normal liver function. CA and PX levels… CONTINUE READING
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