Saliva soluble HLA as a potential marker of response to interferon-β1a in multiple sclerosis: A preliminary study

  title={Saliva soluble HLA as a potential marker of response to interferon-β1a in multiple sclerosis: A preliminary study},
  author={Alireza Minagar and Irena Adamashvili and Roger Everett Kelley and Eduardo C. Gonzalez-Toledo and Jerry McLarty and Stacy J. Smith},
  journal={Journal of Neuroinflammation},
  pages={16 - 16}
Potential surrogate markers of disease activity, including response to therapy, are particularly important in a neurological disorder such as multiple sclerosis (MS) which often has a fluctuating course. Based upon previous studies in our laboratory, we hypothesized that measurement of soluble HLA (sHLA) molecules class II in saliva of MS patients can serve as marker of therapeutic response to high dose interferon beta-1a. We measured the expression patterns of sHLA-II in saliva in 17 patients… CONTINUE READING

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