Saliva or Nasopharyngeal Swab Specimens for Detection of SARS-CoV-2

@article{Wyllie2020SalivaON,
  title={Saliva or Nasopharyngeal Swab Specimens for Detection of SARS-CoV-2},
  author={Anne Louise Wyllie and John B. Fournier and Arnau Casanovas-Massana and Melissa Campbell and Maria Tokuyama and Pavithra Vijayakumar and Joshua L. Warren and Bertie Geng and M. Catherine Muenker and Adam J. Moore and Chantal B. F. Vogels and Mary E. Petrone and Isabel M Ott and Peiwen Lu and Arvind Venkataraman and Alice Lu-Culligan and Jon Klein and Rebecca Earnest and Michael Simonov and Rupak Datta and Ryan Handoko and Nida Naushad and Lorenzo R. Sewanan and Jordan Valdez and Elizabeth B. White and Sarah Lapidus and Chaney C. Kalinich and Xiaodong Jiang and Daniel J. Kim and Eriko Kudo and Melissa M Linehan and Tianyang Mao and Miyu Moriyama and Ji-eun Oh and Annsea Park and Julio Silva and Eric Song and Takehiro Takahashi and Manabu Taura and Orr-El Weizman and Patrick Wong and Yexin Yang and Santos D. Bermejo and Camila D Odio and Saad B. Omer and Charles S. Dela Cruz and Shelli F. Farhadian and Richard A. Martinello and Akiko Iwasaki and Nathan D. Grubaugh and Albert I. Ko},
  journal={The New England Journal of Medicine},
  year={2020}
}
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Saliva is an alternative specimen collection type for Sars-CoV-2 (COVID-19) Polymerase Chain Reaction (PCR) testing and complements other non-NP swab collection methods including throat and nasal swabs for SARS-Cov-2 PCR testing.
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    European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology
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TLDR
Saliva demonstrated good concordance with paired nasopharyngeal swabs for SARS-CoV-2 detection in 67/74 cases (90.5%), though barriers to saliva collection were observed in long-term care residents and outbreak settings, informing appropriate transport time and conditions.
Practical challenges to the clinical implementation of saliva for SARS-CoV-2 detection
TLDR
Saliva demonstrated good concordance with paired nasopharyngeal swabs for SARS-CoV-2 detection in 67/74 cases (90.5%), though barriers to saliva collection were observed in long-term care residents and outbreak settings, informing appropriate transport time and conditions.
Sensitivity of midturbinate versus nasopharyngeal swabs for the detection of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
TLDR
To compare sensitivity of specimens for COVID-19 diagnosis, nasopharyngeal/midturbinate swab pairs from 117 inpatients using reverse-transcriptase polymerase chain reaction (RT-PCR) were tested.
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References

SHOWING 1-6 OF 6 REFERENCES
SARS-CoV-2 Viral Load in Upper Respiratory Specimens of Infected Patients
TLDR
Results of an analysis of nasal and throat swabs from 17 patients in Zhuhai, China, who had received a diagnosis of Covid-19 and found SARS-CoV-2 Viral Load in Upper Respiratory Specimens positive.
Saliva as a Noninvasive Specimen for Detection of SARS-CoV-2
TLDR
Diagnostic testing for COVID-19 is central to controlling the global pandemic and will be a major focus for the next generation of vaccine designers and clinicians.
Self-Collected Oral Fluid and Nasal Swabs Demonstrate Comparable Sensitivity to Clinician Collected Nasopharyngeal Swabs for Covid-19 Detection
TLDR
Supervised self-collection performed comparably to clinician collection and would allow for rapid expansion of testing capacity in the United States by reducing the need for trained healthcare workers, reducing exposure of healthcare workers and reducing the amount of PPE (personal protective equipment) being used for testing during a critical shortage.
SalivaDirect: Simple and sensitive molecular diagnostic test for SARS-CoV-2 surveillance
TLDR
The critical component of the approach is to use saliva instead of respiratory swabs, which enables non-invasive frequent sampling and reduces the need for trained healthcare professionals during collection, and the diagnostic test simplified by not requiring nucleic acid preservatives at sample collection.
Saliva as a non-invasive specimen for detection of SARS-CoV-2
  • J Clin Microbiol 2020;
  • 2020