Saliva or Nasopharyngeal Swab Specimens for Detection of SARS-CoV-2

@article{Wyllie2020SalivaON,
  title={Saliva or Nasopharyngeal Swab Specimens for Detection of SARS-CoV-2},
  author={Anne Louise Wyllie and John B. Fournier and Arnau Casanovas-Massana and Melissa Campbell and Maria Tokuyama and Pavithra Vijayakumar and Joshua L. Warren and Bertie Geng and M. Catherine Muenker and Adam J. Moore and Chantal B. F. Vogels and Mary E. Petrone and Isabel M Ott and Peiwen Lu and Arvind Venkataraman and Alice Lu-Culligan and Jon Klein and Rebecca Earnest and Michael Simonov and Rupak Datta and Ryan Handoko and Nida Naushad and Lorenzo R. Sewanan and Jordan Valdez and Elizabeth B. White and Sarah Lapidus and Chaney C. Kalinich and Xiaodong Jiang and Daniel J. Kim and Eriko Kudo and Melissa M Linehan and Tianyang Mao and Miyu Moriyama and Ji-eun Oh and Annsea Park and Julio Silva and Eric Song and Takehiro Takahashi and Manabu Taura and Orr-El Weizman and Patrick Wong and Yexin Yang and Santos D. Bermejo and Camila D Odio and Saad B. Omer and Charles S. Dela Cruz and Shelli F. Farhadian and Richard A. Martinello and Akiko Iwasaki and Nathan D. Grubaugh and Albert I. Ko},
  journal={The New England Journal of Medicine},
  year={2020}
}
Saliva Specimens to Detect SARS-CoV-2 Infection In this letter, the investigators report that saliva specimens and nasopharyngeal swab specimens had similar sensitivity in the detection of SARS-CoV... 
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The Sensitivity and Costs of Testing for SARS-CoV-2 Infection With Saliva Versus Nasopharyngeal Swabs
This systematic review summarizes evidence comparing the sensitivities for detection of SARS-CoV-2 infection between nasopharyngeal swabs and saliva samples and estimates the incremental cost per…
Diagnostic Yield of Saliva for SARS-CoV-2 Molecular Testing in Children
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Pediatric saliva specimen demonstrated high sensitivity and specificity compared to paired nasopharyngeal swabs (NPS) by Aptima SARS-CoV-2 Assay (Aptima).
The use of saliva as an alternate specimen for SARS-CoV-2 (COVID-19) PCR testing
  • Medicine, Biology
  • 2020
TLDR
Saliva is an alternative specimen collection type for Sars-CoV-2 (COVID-19) Polymerase Chain Reaction (PCR) testing and complements other non-NP swab collection methods including throat and nasal swabs for SARS-Cov-2 PCR testing.
Comparison of nasopharyngeal samples for SARS‐CoV‐2 detection in a paediatric cohort
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It is hypothesised collecting both nasopharyngeal swab and aspirate would improve the diagnostic accuracy of coronavirus disease 2019.
Saliva testing for SARS-CoV-2 in children
Performance of Non-nasopharyngeal Sample Types for Molecular Detection of SARS-CoV-2
Practical challenges to the clinical implementation of saliva for SARS-CoV-2 detection
  • N. Matic, A. Stefanović, C. Lowe
  • Medicine
    European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology
  • 2020
TLDR
Saliva demonstrated good concordance with paired nasopharyngeal swabs for SARS-CoV-2 detection in 67/74 cases (90.5%), though barriers to saliva collection were observed in long-term care residents and outbreak settings, informing appropriate transport time and conditions.
Practical challenges to the clinical implementation of saliva for SARS-CoV-2 detection
TLDR
Saliva demonstrated good concordance with paired nasopharyngeal swabs for SARS-CoV-2 detection in 67/74 cases (90.5%), though barriers to saliva collection were observed in long-term care residents and outbreak settings, informing appropriate transport time and conditions.
Screening for SARS-CoV-2 by RT-PCR: saliva or nasopharyngeal swab? Systematic review and meta-analysis
244 words Main text: 2047 words
Sensitivity of midturbinate versus nasopharyngeal swabs for the detection of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
TLDR
To compare sensitivity of specimens for COVID-19 diagnosis, nasopharyngeal/midturbinate swab pairs from 117 inpatients using reverse-transcriptase polymerase chain reaction (RT-PCR) were tested.
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