Saliva of the Yellow Fever mosquito, Aedes aegypti, modulates murine lymphocyte function

@article{Wasserman2004SalivaOT,
  title={Saliva of the Yellow Fever mosquito, Aedes aegypti, modulates murine lymphocyte function},
  author={H. Wasserman and S. Singh and D. Champagne},
  journal={Parasite Immunology},
  year={2004},
  volume={26}
}
Saliva of many vector arthropods contains factors that inhibit haemostatic responses in their vertebrate hosts. Less is known about the effect of vector saliva on host immune responses. We investigated the effect of Aedes aegypti salivary gland extracts on antigen‐stimulated responses of transgenic OVA‐TCR DO11 mouse splenocytes in vitro. T‐cell proliferation was inhibited in a dose‐dependent manner, with greater than 50% inhibition at 0·3 salivary gland pair (SGP) equivalents/mL. LPS… Expand
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