Saliva carbamazepine levels in children before and during multiple dosing.

@article{Moreland1982SalivaCL,
  title={Saliva carbamazepine levels in children before and during multiple dosing.},
  author={Terry Moreland and David A. Priestman and George Rylance},
  journal={British journal of clinical pharmacology},
  year={1982},
  volume={13 5},
  pages={647-51}
}
1 Saliva carbamazepine (CBZ) pharmacokinetics were determined in six children aged 7-11 years at the start and after 5 weeks of CBZ therapy. 2 A single oral dose of CBZ, 14.7 +/- 2.3 mg kg -1, was administered and mixed saliva was collected at intervals during the next 36 h. CBZ therapy was then continued using the same total daily dose divided into two equal doses. After 5 weeks of therapy saliva samples were collected once more as on day 1. 3 The mean (+/- s.d.) saliva CBZ clearance increased… CONTINUE READING

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