Saliva and plasma quantitative polymerase chain reaction-based detection and surveillance of human papillomavirus-related head and neck cancer.

@article{Ahn2014SalivaAP,
  title={Saliva and plasma quantitative polymerase chain reaction-based detection and surveillance of human papillomavirus-related head and neck cancer.},
  author={Sun Mi Ahn and Jason K. Y. Chan and Zhe Zhang and Hao Wang and Zubair Ali Khan and Justin A Bishop and William H Westra and Wayne M Koch and Joseph A. Califano},
  journal={JAMA otolaryngology-- head & neck surgery},
  year={2014},
  volume={140 9},
  pages={846-54}
}
IMPORTANCE Human papillomavirus type 16 (HPV-16) is a major causative factor in oropharyngeal squamous cell carcinoma (OPSCC). The detection of primary OPSCC is often delayed owing to the challenging anatomy of the oropharynx. OBJECTIVE To investigate the feasibility of HPV-16 DNA detection in pretreatment and posttreatment plasma and saliva and its potential role as a marker of prognosis. DESIGN, SETTING, AND PARTICIPANTS This is a retrospective analysis of a prospectively collected cohort… CONTINUE READING