Salinomycin possesses anti-tumor activity and inhibits breast cancer stem-like cells via an apoptosis-independent pathway.

@article{An2015SalinomycinPA,
  title={Salinomycin possesses anti-tumor activity and inhibits breast cancer stem-like cells via an apoptosis-independent pathway.},
  author={Hyunsook An and Ji Young Kim and Nahyun Lee and Youngkwan Cho and Jae Hong Seo},
  journal={Biochemical and biophysical research communications},
  year={2015},
  volume={466 4},
  pages={696-703}
}
Cancer stem cells (CSCs) play important roles in the formation, growth and recurrence of tumors, particularly following therapeutic intervention. Salinomycin has received recent attention for its ability to target breast cancer stem cells (BCSCs), but the mechanisms of action involved are not fully understood. In the present study, we sought to investigate the mechanisms responsible for salinomycin's selective targeting of BCSCs and its anti-tumor activity. Salinomycin suppressed cell viability… CONTINUE READING
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