Salinomycin inhibits osteosarcoma by targeting its tumor stem cells.

@article{Tang2011SalinomycinIO,
  title={Salinomycin inhibits osteosarcoma by targeting its tumor stem cells.},
  author={Qing-lian Tang and Zhi-Qiang Zhao and Jin-chun Li and Yi Liang and Junqiang Yin and Chang-ye Zou and Xian-biao Xie and Yi-xin Zeng and Jing-nan Shen and Tie-bang Kang and Jin Wang},
  journal={Cancer letters},
  year={2011},
  volume={311 1},
  pages={
          113-21
        }
}
Osteosarcoma is the most common primary bone tumor in children and adolescents and is typically associated with a poor prognosis. Tumor stem cells (TSCs) are presumed to drive tumor initiation and tumor relapse or metastasis. Hence, the poor prognosis of osteosarcoma likely results from a failure to target the osteosarcoma stem cells. Here, we have utilized three different methods to enrich TSCs in osteosarcoma and further evaluated whether salinomycin could selectively target TSCs in… CONTINUE READING
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