Salinomycin induces cell death and differentiation in head and neck squamous cell carcinoma stem cells despite activation of epithelial-mesenchymal transition and Akt

@inproceedings{Kuo2012SalinomycinIC,
  title={Salinomycin induces cell death and differentiation in head and neck squamous cell carcinoma stem cells despite activation of epithelial-mesenchymal transition and Akt},
  author={Selena Z. Kuo and Katherine J. Blair and Elham Rahimy and Alan Kiang and Eric L. Abhold and Jian-Bing Fan and Jessica Wang-Rodriguez and Xabier Altuna and Weg M Ongkeko},
  booktitle={BMC Cancer},
  year={2012}
}
BackgroundCancer stem cells (CSC) are believed to play a crucial role in cancer recurrence due to their resistance to conventional chemotherapy and capacity for self-renewal. Recent studies have reported that salinomycin, a livestock antibiotic, selectively targets breast cancer stem cells 100-fold more effectively than paclitaxel. In our study we sought to determine the effects of salinomycin on head and neck squamous cell carcinoma (HNSCC) stem cells.MethodsMTS and TUNEL assays were used to… CONTINUE READING

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