Salinomycin-induced apoptosis of human prostate cancer cells due to accumulated reactive oxygen species and mitochondrial membrane depolarization.

@article{Kim2011SalinomycininducedAO,
  title={Salinomycin-induced apoptosis of human prostate cancer cells due to accumulated reactive oxygen species and mitochondrial membrane depolarization.},
  author={Kwang-Youn A Kim and Sun-Nyoung Yu and Sun-Yi Lee and Sung-Sik Chun and Yong-Lark Choi and Y K Park and Chung Seog Song and Bandana Chatterjee and Soon-Cheol Ahn},
  journal={Biochemical and biophysical research communications},
  year={2011},
  volume={413 1},
  pages={80-6}
}
The anticancer activity of salinomycin has evoked excitement due to its recent identification as a selective inhibitor of breast cancer stem cells (CSCs) and its ability to reduce tumor growth and metastasis in vivo. In prostate cancer, similar to other cancer types, CSCs and/or progenitor cancer cells are believed to drive tumor recurrence and tumor growth. Thus salinomycin can potentially interfere with the end-stage progression of hormone-indifferent and chemotherapy-resistant prostate… CONTINUE READING

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