Salidroside ameliorates insulin resistance through activation of a mitochondria-associated AMPK/PI3K/Akt/GSK3β pathway.

@article{Zheng2015SalidrosideAI,
  title={Salidroside ameliorates insulin resistance through activation of a mitochondria-associated AMPK/PI3K/Akt/GSK3β pathway.},
  author={Tao Zheng and Xiaoyan Yang and Dan Wu and Shasha Xing and Fang Bian and Wenjing Li and Jiangyang Chi and Xiangli Bai and Guangjie Wu and Xiaoqian Chen and Yonghui Zhang and Si Jin},
  journal={British journal of pharmacology},
  year={2015},
  volume={172 13},
  pages={3284-301}
}
BACKGROUND AND PURPOSE Recent reports have suggested that salidroside could protect cardiomyocytes from oxidative injury and stimulate glucose uptake in skeletal muscle cells by activating AMP-activated protein kinase (AMPK). The aim of this study was to evaluate the therapeutic effects of salidroside on diabetic mice and to explore the underlying mechanisms. EXPERIMENTAL APPROACH The therapeutic effects of salidroside on type 2 diabetes were investigated. Increasing doses of salidroside (25… CONTINUE READING
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