Salicylate reduces susceptibility of Mycobacterium tuberculosis to multiple antituberculosis drugs.

  title={Salicylate reduces susceptibility of Mycobacterium tuberculosis to multiple antituberculosis drugs.},
  author={Alain Schaller and Zhonghe Sun and Yongping Yang and Akos Somoskovi and Ying Zhang},
  journal={Antimicrobial agents and chemotherapy},
  volume={46 8},
Salicylate induces multiple antibiotic resistance in various bacterial species. Here we investigated the effect of salicylate on the susceptibility of Mycobacterium tuberculosis to a range of antituberculosis (anti-TB) drugs. In the presence of salicylate, the killing effects of isoniazid (INH), rifampin (RMP), ethambutol (EMB), streptomycin (STR), and p-aminosalicylate (PAS) were reduced, as shown with a tetrazolium redox dye viability assay and a bacterial survival assay. Salicylate-induced… CONTINUE READING


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Publications referenced by this paper.
Showing 1-10 of 11 references

The effects of salicylate on bacteria.

The international journal of biochemistry & cell biology • 2000
View 2 Excerpts

Antituberculosis activity of certain antifungal and antihelmintic drugs.

Tubercle and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease • 1999