Salicylate reduces susceptibility of Mycobacterium tuberculosis to multiple antituberculosis drugs.

@article{Schaller2002SalicylateRS,
  title={Salicylate reduces susceptibility of Mycobacterium tuberculosis to multiple antituberculosis drugs.},
  author={Alain Schaller and Zhonghe Sun and Yongping Yang and Akos Somoskovi and Ying Zhang},
  journal={Antimicrobial agents and chemotherapy},
  year={2002},
  volume={46 8},
  pages={
          2636-9
        }
}
Salicylate induces multiple antibiotic resistance in various bacterial species. Here we investigated the effect of salicylate on the susceptibility of Mycobacterium tuberculosis to a range of antituberculosis (anti-TB) drugs. In the presence of salicylate, the killing effects of isoniazid (INH), rifampin (RMP), ethambutol (EMB), streptomycin (STR), and p-aminosalicylate (PAS) were reduced, as shown with a tetrazolium redox dye viability assay and a bacterial survival assay. Salicylate-induced… CONTINUE READING

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