Salicylate metabolites inhibit cyclooxygenase-2-dependent prostaglandin E(2) synthesis in murine macrophages.

@article{Hinz2000SalicylateMI,
  title={Salicylate metabolites inhibit cyclooxygenase-2-dependent prostaglandin E(2) synthesis in murine macrophages.},
  author={B. Hinz and V. Kraus and A. Pahl and K. Brune},
  journal={Biochemical and biophysical research communications},
  year={2000},
  volume={274 1},
  pages={
          197-202
        }
}
  • B. Hinz, V. Kraus, +1 author K. Brune
  • Published 2000
  • Chemistry, Medicine
  • Biochemical and biophysical research communications
The poor cyclooxygenase (COX) inhibitor and major aspirin metabolite salicylic acid is known to exert analgesic and anti-inflammatory effects by still unidentified mechanisms. In RAW 264.7 macrophages, lipopolysaccharide (LPS)-induced COX-2-dependent synthesis of prostaglandin E(2) (PGE(2)) was suppressed by aspirin (IC(50) of 5. 35 microM), whereas no significant inhibition was observed in the presence of sodium salicylate and the salicylate metabolite salicyluric acid at concentrations up to… Expand
Inhibition of Prostaglandin H2 Synthases by Salicylate Is Dependent on the Oxidative State of the Enzymes
Sodium salicylate enhances the expression of cyclooxygenase-2 in endotoxin-stimulated human mononuclear cells.
Cyclooxygenase-2--10 years later.
  • B. Hinz, K. Brune
  • Medicine
  • The Journal of pharmacology and experimental therapeutics
  • 2002
Anti-inflammatory effects of aspirin and sodium salicylate.
Flurbiprofen Enantiomers Inhibit Inducible Nitric Oxide Synthase Expression in RAW 264.7 Macrophages
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