Salicylate inhibits the renal transport of inorganic sulfate in rat membrane vesicle preparations.

@article{Darling1994SalicylateIT,
  title={Salicylate inhibits the renal transport of inorganic sulfate in rat membrane vesicle preparations.},
  author={Inger M. Darling and M L Mammarella and Qing Chen and Marilyn E Morris},
  journal={Drug metabolism and disposition: the biological fate of chemicals},
  year={1994},
  volume={22 2},
  pages={318-23}
}
Salicylic acid (SA) administration produces a pronounced enhancement of the renal clearance of inorganic sulfate in rats. The purpose of the present investigation was to determine if SA inhibits the renal transport of inorganic sulfate in rat kidney cortex brush border membrane (BBM) and basolateral membrane (BLM) vesicle preparations. Sodium-dependent cotransport of inorganic sulfate was examined in BBM, and the values for KM and Vmax, determined using nonlinear regression analysis, were 0.52… CONTINUE READING