Salicylate blocks L-type calcium channels in rat inferior colliculus neurons

@article{Liu2005SalicylateBL,
  title={Salicylate blocks L-type calcium channels in rat inferior colliculus neurons},
  author={Yanxing Liu and Xuepei Li and Changsheng Ma and Junxiu Liu and Hong Yong Lu},
  journal={Hearing Research},
  year={2005},
  volume={205},
  pages={271-276}
}
To investigate the effects of the tinnitus inducer sodium salicylate on L-type voltage-gated calcium channels, we studied freshly dissociated inferior colliculus neurons of rats by the whole-cell voltage clamp method. Salicylate's blocking of L-type calcium channels was concentration dependent, and the IC(50) value of salicylate was estimated to be 1.99 mM. An amount of 1 mM salicylate significantly shifted the steady-state inactivation curve of L-type calcium channels about 9 mV in the… CONTINUE READING
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