Salbutamol-induced increased airway responsiveness to allergen and reduced protection versus methacholine: dose response.

@article{Bhagat1996SalbutamolinducedIA,
  title={Salbutamol-induced increased airway responsiveness to allergen and reduced protection versus methacholine: dose response.},
  author={Rajesh Bhagat and Veronica A. Swystun and Donald W. Cockcroft},
  journal={The Journal of allergy and clinical immunology},
  year={1996},
  volume={97 1 Pt 1},
  pages={
          47-52
        }
}
Interaction of inhaled beta 2 agonist and inhaled corticosteroid on airway responsiveness to allergen and methacholine.
TLDR
Neither the dose shift nor its significant reduction by regularly used beta 2 agonist were influenced by the inhaled corticosteroid.
Rapid onset of tolerance to the bronchoprotective effect of salmeterol.
TLDR
Tolerance to the acute bronchoprotective effect of salmeterol was significant after the first two doses and progressively increased to the seventh dose, and also assessed cross-tolerance with salbutamol.
Effect of chronic theophylline treatment on the methacholine dose-response curve in allergic asthmatic subjects.
TLDR
Chronic treatment with theophylline reduces the reactivity of the airways to methacholine, which might be beneficial in the treatment of persistent asthma.
Regular inhaled salbutamol : effect on airway responsiveness to methacholine and adenosine 5'-monophosphate and tolerance to bronchoprotection.
TLDR
Regular salbutamol treatment did not enhance airway responsiveness to either the indirect bronchoconstrictor AMP or the direct bronchconstrictors methacholine, and compared to its effect on methcholine, sal butamol had a greater acute protective effect vs AMP and produced greater loss of protection against AMP when used regularly.
Salbutamol tolerance to bronchoprotection: course of onset.
Regular use effect of inhaled ipratropium bromide and methacholine responsiveness in well-controlled asthma
TLDR
Evidence is provided that regular use of inhaled ipratropium does not result in loss of bronchoprotection or lead to rebound hyperresponsiveness following treatment withdrawal and Muscarinic antagonists appear to have a superior safety profile over β2-agonist use in the treatment of asthma.
Tolerance to the bronchoprotective effect of salmeterol 12 hours after starting twice daily treatment.
Comparison of the relative efficacy of formoterol and salmeterol in asthmatic patients.
TLDR
Data show that salmeterol is a partial agonist on the beta2-receptor in relation to formoterol in human airways in vivo, and further studies are required to document the clinical consequences of this finding, for example in severe asthmatic patients.
Effects of terbutaline and budesonide on sputum cells and bronchial hyperresponsiveness in asthma.
TLDR
The hypothesis that short-acting beta-agonists have a permissive effect on airway inflammation and that when used in high dose there may be an unfavorable interaction with inhaled corticosteroids is supported.
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References

SHOWING 1-10 OF 20 REFERENCES
Interaction of inhaled beta 2 agonist and inhaled corticosteroid on airway responsiveness to allergen and methacholine.
TLDR
Neither the dose shift nor its significant reduction by regularly used beta 2 agonist were influenced by the inhaled corticosteroid.
Tolerance to the Nonbronchodilator Effects of Inhaled β2-Agonists in Asthma
TLDR
This randomized, double-blind, crossover study investigated whether tolerance develops to the protective effect of inhaled terbutaline on airway responsiveness to the bronchoconstrictors methacholine and AMP during sustained treatment with terbutalin.
Long-term effects of a long-acting beta 2-adrenoceptor agonist, salmeterol, on airway hyperresponsiveness in patients with mild asthma.
TLDR
Regular treatment of patients with mild asthma with salmeterol leads to tolerance to its protective effects against a bronchoconstrictor stimulus, in this case inhaled methacholine, despite well-maintained bronchodilation, which raises concern about the effectiveness of prolonged therapy with long-acting beta 2-adrenoceptor agonists in asthma.
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