Salacia oblonga root improves cardiac lipid metabolism in Zucker diabetic fatty rats: modulation of cardiac PPAR-alpha-mediated transcription of fatty acid metabolic genes.

@article{Huang2006SalaciaOR,
  title={Salacia oblonga root improves cardiac lipid metabolism in Zucker diabetic fatty rats: modulation of cardiac PPAR-alpha-mediated transcription of fatty acid metabolic genes.},
  author={Tom Hsun-Wei Huang and Qinglin Yang and Masaki Harada and Jasna Uberai and Jane Radford and George Li and Johji Yamahara and Basil D. Roufogalis and Yuhao Li},
  journal={Toxicology and applied pharmacology},
  year={2006},
  volume={210 1-2},
  pages={78-85}
}
Excess cardiac triglyceride accumulation in diabetes and obesity induces lipotoxicity, which predisposes the myocytes to death. On the other hand, increased cardiac fatty acid (FA) oxidation plays a role in the development of myocardial dysfunction in diabetes. PPAR-alpha plays an important role in maintaining homeostasis of lipid metabolism. We have previously demonstrated that the extract from Salacia oblonga root (SOE), an Ayurvedic anti-diabetic and anti-obesity medicine, improves… CONTINUE READING
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