Saikosaponin-D reduces cisplatin-induced nephrotoxicity by repressing ROS-mediated activation of MAPK and NF-κB signalling pathways.

@article{Ma2015SaikosaponinDRC,
  title={Saikosaponin-D reduces cisplatin-induced nephrotoxicity by repressing ROS-mediated activation of MAPK and NF-κB signalling pathways.},
  author={Xiaobin Ma and Chengxue Dang and Huafeng Kang and Zhijun Dai and Shuai Lin and Haitao Guan and Xiaoxu Liu and Xijing Wang and Wentao Hui},
  journal={International immunopharmacology},
  year={2015},
  volume={28 1},
  pages={399-408}
}
The nephrotoxicity induced by cisplatin (DDP) severely limits the clinical efficacy of this widely used anticancer agent. The observed nephrotoxicity may be the result of DDP-induced inflammation and apoptosis. Saikosaponin-D (SSD), a triterpenoid saponin, has numerous pharmacological properties. The goal of the present study was to investigate whether and how SSD protected against DDP-induced nephrotoxicity. Non-cytotoxic levels of SSD significantly increased the viability rate, improved the… CONTINUE READING