Safrole Induces Apoptosis in Human Oral Cancer HSC-3 Cells

  title={Safrole Induces Apoptosis in Human Oral Cancer HSC-3 Cells},
  author={Fu-shun Yu and J. Yang and C-S Yu and C-C Lu and Jo-Hua Chiang and C-W Lin and J. Chung},
  journal={Journal of Dental Research},
  pages={168 - 174}
Phytochemicals have been used as potential chemopreventive or chemotherapeutic agents. However, there are data suggesting a mutagenic effect of some phytochemicals. We hypothesized that safrole would have anticancer effects on human oral squamous cell carcinoma HSC-3 cells. Safrole decreased the percentage of viable HSC-3 cells via induction of apoptosis by an increased level of cytosolic Ca2+ and a reduction in the mitochondrial membrane potential (ΔΨ m ). Changes in the membrane potential… Expand
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