Safingol (L-threo-sphinganine) induces autophagy in solid tumor cells through inhibition of PKC and the PI3-kinase pathway.

@article{Coward2009SafingolI,
  title={Safingol (L-threo-sphinganine) induces autophagy in solid tumor cells through inhibition of PKC and the PI3-kinase pathway.},
  author={Jesse W. Coward and Grazia Ambrosini and Elgilda Musi and J. Kelly Truman and Adriana Haimovitz-Friedman and Jeremy C. Allegood and Elaine Ying Wang and Alfred H. Merrill and Gary K. Schwartz},
  journal={Autophagy},
  year={2009},
  volume={5 2},
  pages={184-93}
}
Safingol, the synthetic L-threo-stereoisomer of endogenous (D-erythro-) sphinganine, is an inhibitor of protein kinase C and sphingosine kinase in vitro, and in some cell types has been implicated in ceramide generation and induction of apoptosis. Utilizing electron microscopy, acridine orange staining, and immunoblot and fluorescent localization studies of the myosin light chain-associated protein (LC3), we determined that safingol induces cell death of an exclusively autophagic character and… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 34 extracted citations

The roles of PKCs in regulating autophagy

Journal of Cancer Research and Clinical Oncology • 2018

Sphingosine-1-phosphate metabolism: A structural perspective.

Critical reviews in biochemistry and molecular biology • 2015
View 1 Excerpt

Similar Papers

Loading similar papers…