Safety study of intraarticular injection of interleukin 1 receptor antagonist in patients with painful knee osteoarthritis: a multicenter study.

@article{Chevalier2005SafetySO,
  title={Safety study of intraarticular injection of interleukin 1 receptor antagonist in patients with painful knee osteoarthritis: a multicenter study.},
  author={Xavier Chevalier and B. Giraudeau and Thierry Conrozier and Jocelyne Marliere and Philippe Kiefer and Philippe Goupille},
  journal={The Journal of rheumatology},
  year={2005},
  volume={32 7},
  pages={1317-23}
}
OBJECTIVE Interleukin 1 (IL-1) plays a pivotal role in the pathogenesis of osteoarthritis (OA). In animal models of OA, IL-1 blockade by IL-1 receptor antagonist (IL-1Ra) can slow the progression of disease. We examined the safety of intraarticular (IA) injections of recombinant human IL-1Ra in patients with knee OA. METHODS A prospective multicenter trial was conducted using the continual reassessment method. Six doses were considered, 0.05 mg up to 150 mg IL-1Ra, and the trial was double… CONTINUE READING
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