Safety studies on intravenous administration of oncolytic recombinant vesicular stomatitis virus in purpose-bred beagle dogs.

@article{Leblanc2013SafetySO,
  title={Safety studies on intravenous administration of oncolytic recombinant vesicular stomatitis virus in purpose-bred beagle dogs.},
  author={Amy K Leblanc and Shruthi K Naik and Gina D Galyon and Nathan J Jenks and Mike B Steele and K F Peng and Mark J. Federspiel and Robert Mc Donnell and Stephen Russell},
  journal={Human gene therapy. Clinical development},
  year={2013},
  volume={24 4},
  pages={174-81}
}
VSV-IFNβ-NIS is a novel recombinant oncolytic vesicular stomatitis virus (VSV) with documented efficacy and safety in preclinical murine models of cancer. To facilitate clinical translation of this promising oncolytic therapy in patients with disseminated cancer, we are utilizing a comparative oncology approach to gather data describing the safety and efficacy of systemic VSV-IFNβ-NIS administration in dogs with naturally occurring cancer. In support of this, we executed a dose-escalation study… CONTINUE READING
Highly Cited
This paper has 32 citations. REVIEW CITATIONS

Citations

Publications citing this paper.
Showing 1-10 of 16 extracted citations

Similar Papers

Loading similar papers…