Safety studies of l-alanyl-l-glutamine (l-AG).

@article{Oda2008SafetySO,
  title={Safety studies of l-alanyl-l-glutamine (l-AG).},
  author={Shigehito Oda and T Mullaney and Austin J. Bowles and Robert F. Durward and Barry G. Lynch and Yu Sugimura},
  journal={Regulatory toxicology and pharmacology : RTP},
  year={2008},
  volume={50 2},
  pages={
          226-38
        }
}
The safety of l-alanyl-l-glutamine (l-AG) derived by fermentation using a recombinant Escherichia coli strain containing the l-amino acid alpha-ligase gene from Bacillus subtilis, was assessed in acute and subchronic toxicity studies in the rat. l-AG was tested in vitro in a bacterial reverse mutation assay and in a chromosome aberration assay. l-AG was not acutely toxic when administered to Sprague-Dawley rats by gavage at 2000mg/kg bw. In a 14-day range-finding study, l-AG at up to 5% in the… CONTINUE READING