Safety review of adult clinical trial experience with lamotrigine.

@article{Messenheimer1998SafetyRO,
  title={Safety review of adult clinical trial experience with lamotrigine.},
  author={John A. Messenheimer and E. L. Mullens and Letizia Giorgi and Frank G. Young},
  journal={Drug safety},
  year={1998},
  volume={18 4},
  pages={
          281-96
        }
}
To date approximately 4000 adults > 12 years of age have been treated with lamotrigine in Glaxo Wellcome sponsored clinical trials. Review of the data from these trials shows lamotrigine to be effective and well tolerated in both add-on and monotherapy treatment. Safety of lamotrigine was comparable to that of other anticonvulsants in add-on controlled clinical trials. In addition, fewer than half the number of patients in monotherapy studies who were taking lamotrigine discontinued treatment… CONTINUE READING

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