Safety results of two phase III trials of an intravitreous injection of highly purified ovine hyaluronidase (Vitrase) for the management of vitreous hemorrhage.

@article{Kuppermann2005SafetyRO,
  title={Safety results of two phase III trials of an intravitreous injection of highly purified ovine hyaluronidase (Vitrase) for the management of vitreous hemorrhage.},
  author={Baruch D. Kuppermann and Edgar L Thomas and Marc D de Smet and Lisa R. Grillone},
  journal={American journal of ophthalmology},
  year={2005},
  volume={140 4},
  pages={585-97}
}
PURPOSE To evaluate the safety of intravitreous ovine hyaluronidase for the management of vitreous hemorrhage. DESIGN Two prospective, randomized, placebo-controlled, double-masked studies. Pooled efficacy data are presented in a companion article in this issue of The Journal. METHODS Subjects with vitreous hemorrhage > or = 1 month, severe at entry and best corrected visual acuity (BCVA) worse than 20/200 in the study eye were randomized to 7.5 IU, 55 IU, 75 IU ovine hyaluronidase, saline… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 23 extracted citations

Similar Papers

Loading similar papers…