Safety profile of pneumococcal conjugate vaccines: systematic review of pre- and post-licensure data.

  title={Safety profile of pneumococcal conjugate vaccines: systematic review of pre- and post-licensure data.},
  author={Frank Destefano and Dina Pfeifer and Hanna Nohynek},
  journal={Bulletin of the World Health Organization},
  volume={86 5},
A 7-valent pneumococcal polysaccharide-protein conjugate vaccine (PCV7) was licensed in the United States of America in 2000, but no comprehensive postmarketing review of safety has been carried out. We conducted a systematic review of the safety of PCV7 and other pneumococcal conjugate vaccines. A total of 42 studies were included in the review. Reactogenicity data from some randomized trials suggest that PCV7 may result in more local reactions and fever than certain comparison vaccines… CONTINUE READING
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