Safety of tumour necrosis factor-alpha antagonists.

  title={Safety of tumour necrosis factor-alpha antagonists.},
  author={Dinesh Khanna and Maureen McMahon and Daniel e. Furst},
  journal={Drug safety},
  volume={27 5},
Tumour necrosis factor-alpha (TNFalpha) is a proinflammatory cytokine that is synthesised by a variety of cell types in response to infectious or inflammatory stimuli. Although TNFalpha plays an adaptive role in immune protection and wound healing at 'physiological' levels, excess TNFalpha production can lead to adverse consequences. TNFalpha is a pivotal cytokine involved in the pathogenesis and progression of rheumatoid arthritis (RA). TNFalpha antagonists have been shown to be effective in… CONTINUE READING
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