Safety of treatment of metastatic breast cancer with trastuzumab beyond disease progression.

@article{Tripathy2004SafetyOT,
  title={Safety of treatment of metastatic breast cancer with trastuzumab beyond disease progression.},
  author={Debu Tripathy and Dennis J. Slamon and Melody A. Cobleigh and Andrew Arnold and Mansoor Saleh and Joanne Mortimer and Maureen 3 Murphy and Stanford J. Stewart},
  journal={Journal of clinical oncology : official journal of the American Society of Clinical Oncology},
  year={2004},
  volume={22 6},
  pages={1063-70}
}
PURPOSE In a pivotal phase III trial, the addition of trastuzumab to chemotherapy significantly improved response rate, time to disease progression, and overall survival in women with HER2 overexpressing metastatic breast cancer. We conducted an extension study to this trial to obtain additional safety information and to provide trastuzumab following disease progression. PATIENTS AND METHODS A total of 247 patients with documented disease progression received weekly intravenous trastuzumab in… CONTINUE READING

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