Safety of titanium dioxide nanoparticles in cosmetics

  title={Safety of titanium dioxide nanoparticles in cosmetics},
  author={Brigitte Dr{\'e}no and Andrew F. Alexis and Bertrand Chuberre and Marina Marinovich},
  journal={Journal of the European Academy of Dermatology and Venereology},
Titanium dioxide (TiO2) is widely used in a variety of products including cosmetics. TiO2 in its nanoparticle form (nano‐TiO2) is now the only form used as an ultraviolet (UV) filter in sunscreens, but also in some day creams, foundations and lip balms. While its efficacy as a UV filter is proven in the prevention of skin cancers and sunburns, some concerns have been raised about its safety. Indeed, considering its small size, nano‐TiO2 is suspected to penetrate dermal, respiratory or… 

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Titanium Dioxide in Commercial Sunscreens: the Morphological Characterization and the Quantification

  • I. PrimadonaF. Dara M. Nasir
  • Materials Science
    International Journal on Advanced Science, Engineering and Information Technology
  • 2021
Due to nanotechnology's advancement, the application of nanomaterials in commercial products, including in sunscreens, has been increased rapidly. Physical sunscreens employ Titanium dioxide (TiO2)

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Investigating whether TiO2 nanoparticles in a commercial sunscreen could penetrate intact or sunburned skin in a real-life scenario with UVB exposure and standardized sunscreen applications on human volunteers found no evidence of skin penetration.

Lack of significant dermal penetration of titanium dioxide from sunscreen formulations containing nano- and submicron-size TiO2 particles.

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Overall, an increase in apoptosis is reported, which may be caspase 8/Fas-dependent, and that the H2TiO7 nanoparticles, despite their smaller particle size, had no significant enhanced effect on HaCaT cells as compared to Fine and Ultrafine forms of TiO2.

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The stratum corneum of the HSEM may limit penetration of metal nanoparticles to induce toxicity, and these particles were not dermal irritants under the conditions used in this study.

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Treatment with sTiO(2) or ncTiO (2) did not promote skin carcinogenesis in mice or rats, probably due to lack of penetration through the epidermis.

Sunscreens with Titanium Dioxide (TiO2) Nano-Particles: A Societal Experiment

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