Safety of the selective costimulation modulator abatacept in rheumatoid arthritis patients receiving background biologic and nonbiologic disease-modifying antirheumatic drugs: A one-year randomized, placebo-controlled study.

@article{Weinblatt2006SafetyOT,
  title={Safety of the selective costimulation modulator abatacept in rheumatoid arthritis patients receiving background biologic and nonbiologic disease-modifying antirheumatic drugs: A one-year randomized, placebo-controlled study.},
  author={Michael E. Weinblatt and Bernard G Combe and Allison Covucci and Richard Aranda and J{\"u}rgen C. Becker and Edward Keystone},
  journal={Arthritis and rheumatism},
  year={2006},
  volume={54 9},
  pages={
          2807-16
        }
}
OBJECTIVE To assess the safety of abatacept, a selective costimulation modulator, in patients with active rheumatoid arthritis (RA) who had been receiving > or =1 traditional nonbiologic and/or biologic disease-modifying antirheumatic drugs (DMARDs) approved for the treatment of RA for at least 3 months prior to entry into the study. METHODS This was a 1-year, multicenter, randomized, double-blind, placebo-controlled trial. Patients were randomized 2:1 to receive abatacept at a fixed dose… CONTINUE READING

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