Safety of prothrombin complex concentrates for rapid anticoagulation reversal of vitamin K antagonists. A meta-analysis.

@article{Dentali2011SafetyOP,
  title={Safety of prothrombin complex concentrates for rapid anticoagulation reversal of vitamin K antagonists. A meta-analysis.},
  author={Francesco Dentali and Chiara Marchesi and Matteo Giorgi Pierfranceschi and Mark Andrew Crowther and David Antol{\'i}n Garc{\'i}a and Elaine M. Hylek and Daniel M. Witt and Nathan P. Clark and Alessandro Squizzato and Davide Imberti and Walter Ageno},
  journal={Thrombosis and haemostasis},
  year={2011},
  volume={106 3},
  pages={429-38}
}
Prothrombin complex concentrates (PCCs) are recommended as the treatment of choice in warfarin-related coagulopathy. However, the risk of thromboembolic complications associated with their use is not well defined. We performed a meta-analysis to estimate the rate of thromboembolic complications in patients receiving vitamin K antagonists (VKAs) treated with PCCs for bleeding or before urgent surgery. Medline and Embase databases were searched. Two reviewers performed study selection and… CONTINUE READING