Safety of mefloquine and other antimalarial agents in the first trimester of pregnancy.

@article{PhillipsHoward1998SafetyOM,
  title={Safety of mefloquine and other antimalarial agents in the first trimester of pregnancy.},
  author={Penelope A Phillips-Howard and Robert Steffen and L. H. Glenton Kerr and Bart Vanhauwere and J Schildknecht and E. Fuchs and Rob Edwards},
  journal={Journal of travel medicine},
  year={1998},
  volume={5 3},
  pages={121-6}
}
BACKGROUND Safe and effective antimalarials are required to protect pregnant women from the harmful effects of malaria. METHODS Data were collected from two separate prospective cohorts to ascertain the safety of chloroquine-proguanil, sulfadoxine-pyrimethamine (SP), and mefloquine taken in the first trimester of pregnancy. RESULTS In a traveler cohort of 236 pregnant women, spontaneous abortions were reported in 7.6% of 99 women taking chloroquine-proquanil, 0% of 19 taking sulfadoxine… CONTINUE READING