Safety of local anesthetics administered intrathecally in diabetic rats.

@article{Kroin2012SafetyOL,
  title={Safety of local anesthetics administered intrathecally in diabetic rats.},
  author={Jeffrey S. Kroin and Asokumar Buvanendran and Kenneth J. Tuman and James M Kerns},
  journal={Pain medicine},
  year={2012},
  volume={13 6},
  pages={802-7}
}
OBJECTIVES Although retrospective studies show the risk of neurological complications after spinal anesthesia with local anesthetics is small in diabetic patients, there is still concern about the safety of different local anesthetics in diabetics undergoing neuroaxial anesthesia. We examined block duration and histology of spinal cord and roots with intrathecal local anesthetics in diabetic rats. METHODS Rats were made diabetic with streptozotocin injection. Blood glucose levels confirmed… CONTINUE READING