Safety of intravenous administration of a canarypox virus encoding the human wild-type p53 gene in colorectal cancer patients

Abstract

Overexpression of p53 occurs in more than 50% of colorectal cancers. Therefore, p53 represents an attractive target antigen for immunotherapy. We assessed the safety of a canarypox virus encoding the human wild-type p53 gene given intravenously to end-stage colorectal cancer patients in a three-step dose escalation study aimed at inducing p53 immune… (More)
DOI: 10.1038/sj.cgt.7700600

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