Safety of intrathecal sodium nitroprusside for the treatment and prevention of refractory cerebral vasospasm and ischemia in humans.

@article{Thomas1999SafetyOI,
  title={Safety of intrathecal sodium nitroprusside for the treatment and prevention of refractory cerebral vasospasm and ischemia in humans.},
  author={Jeffrey E Thomas and R H Rosenwasser and Rocco Armonda and J Harrop and Wayne Mitchell and Irfan Galaria},
  journal={Stroke},
  year={1999},
  volume={30 7},
  pages={1409-16}
}
BACKGROUND AND PURPOSE The delayed type of cerebral vasoconstriction known as cerebral vasospasm (DCV) remains an important cause of permanent neurological injury and death following aneurysmal subarachnoid hemorrhage despite best current medical therapy. The mechanism of DCV remains unknown. A new treatment for refractory DCV using intrathecally delivered sodium nitroprusside and results in 21 patients is reported. METHODS Candidates for treatment were patients with secured cerebral… CONTINUE READING

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