Safety of high-dose nicotinamide: a review

  title={Safety of high-dose nicotinamide: a review},
  author={Mikael Knip and Isabelle F Douek and William P. Moore and H. A. Gillmor and A. E. M. Mclean and Polly J. Bingley and Edwin A. M. Gale and for the Diabetes Prevention Program Research Group},
Abstract Nicotinamide, the amide derivative of nicotinic acid, has over the past forty years been given at high doses for a variety of therapeutic applications. It is currently in trial as a potential means of preventing the onset of Type I (insulin-dependent) diabetes mellitus in high-risk, first-degree relatives. Nicotinamide is for regulatory purposes classed as a food additive rather than a drug and has not therefore required the formal safety evaluation normally expected of a new therapy… Expand
Possible Adverse Effects of High-Dose Nicotinamide: Mechanisms and Safety Assessment
A collective literature search was performed to provide a comprehensive list of possible adverse effects of NAM and to provide understanding of their underlying mechanisms and assessment of the raised safety concerns, which assures safety in current usage level of N AM, but also finds potential risks for epigenetic alterations associated with chronic use of Nam at high doses. Expand
Effect of oral administration of nicotinamide mononucleotide on clinical parameters and nicotinamide metabolite levels in healthy Japanese men.
The single oral administration of NMN was safe and effectively metabolized in healthy men without causing any significant deleterious effects, implicating a potential therapeutic strategy to mitigate aging-related disorders in humans. Expand
Diverse therapeutic efficacies and more diverse mechanisms of nicotinamide
NAM, by itself or through altering metabolic balance of NAD+ and tryptophan, modulates mitochondrial function and activities of many molecules and thereby positively affects cell viability and metabolic functions and appears to be quite safe with limited possibility of side effects which are related to NAM’s metabolites. Expand
The Role of Nicotinamide in Cancer Chemoprevention and Therapy
Nicotinamide has potential as a safe, well-tolerated, and cost-effective agent to be used in cancer chemoprevention and therapy, however, more preclinical studies and clinical trials are needed to fully unravel its value. Expand
A review of nicotinamide: treatment of skin diseases and potential side effects
  • H. Rolfe
  • Chemistry, Medicine
  • Journal of cosmetic dermatology
  • 2014
The possible side effects and consequences of excessive Nicotinamide exposure are reviewed, including suggestions nicotinamide might have a role in the development of diabetes, Parkinson's disease, and liver damage. Expand
Effect of standard nicotinamide in the prevention of type 1 diabetes in first degree relatives of persons with type 1 diabetes
Type 1 diabetes prevention trial using standard nicotinamide is feasible but fails to prevent or delay the disease onset at the dose the authors used. Expand
New evidence for nicotinic acid treatment to reduce atherosclerosis
Emerging evidence from clinical and basic research studies indicates that novel direct antiatherosclerotic properties might mediate nicotinic acid-induced cardiovascular protection. Expand
Oral nicotinamide: The role in skin cancer chemoprevention
Efficacy and safety of NAM was evaluated in a Phase III double‐blinded control‐placebo study (ONTRAC), thus demonstrating that the incidence of actinic keratoses and non‐melanoma skin cancers was lower in the nicotinamide group than in placebo group. Expand
The Influence of Nicotinamide on Health and Disease in the Central Nervous System
A body of research investigating the role of nicotinamide in neuronal health within the CNS is summarized, with a focus on studies that have shown a neuroprotective effect. Expand
[Safety and effectiveness of nicotinic acid in the management of patients with chronic renal disease and hyperlipidemia associated to hyperphosphatemia].
The nicotinic acid is efficient, very well tolerated and economical in comparison with others drugs, which makes it ideal for the treatment of patients with hyperlipidaemia and refractory hyperphosphatemia to the classical treatments. Expand