Safety of high-dose nicotinamide: a review

@article{Knip2000SafetyOH,
  title={Safety of high-dose nicotinamide: a review},
  author={Mikael Knip and Isabelle F Douek and William P. Moore and H. A. Gillmor and A. E. M. Mclean and Polly J. Bingley and Edwin A. M. Gale and for the Diabetes Prevention Program Research Group},
  journal={Diabetologia},
  year={2000},
  volume={43},
  pages={1337-1345}
}
Abstract Nicotinamide, the amide derivative of nicotinic acid, has over the past forty years been given at high doses for a variety of therapeutic applications. It is currently in trial as a potential means of preventing the onset of Type I (insulin-dependent) diabetes mellitus in high-risk, first-degree relatives. Nicotinamide is for regulatory purposes classed as a food additive rather than a drug and has not therefore required the formal safety evaluation normally expected of a new therapy… Expand
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  • 2014
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Type 1 diabetes prevention trial using standard nicotinamide is feasible but fails to prevent or delay the disease onset at the dose the authors used. Expand
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