Safety of granulocyte colony-stimulating factor (filgrastim) in intubated patients in the intensive care unit: interim analysis of a prospective, placebo-controlled, double-blind study.

@article{Pettil2000SafetyOG,
  title={Safety of granulocyte colony-stimulating factor (filgrastim) in intubated patients in the intensive care unit: interim analysis of a prospective, placebo-controlled, double-blind study.},
  author={Ville Pettil{\"a} and Olli S Takkunen and Tero Varpula and Antti Markkola and Kimmo V.K. Porkka and Ville V. Valtonen},
  journal={Critical care medicine},
  year={2000},
  volume={28 11},
  pages={
          3620-5
        }
}
OBJECTIVE To investigate the safety of the granulocyte colony-stimulating factor filgrastim in the prevention of nosocomial infections in intubated patients in the intensive care unit (ICU), with special emphasis on the possible deleterious effect on acute respiratory distress syndrome (ARDS) and the development of multiple organ dysfunction (MOD). DESIGN Predetermined, interim analysis of a prospective, randomized, placebo-controlled, double-blind trial. SETTING University hospital medical… CONTINUE READING
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