Safety of delayed leucovorin "rescue" following high-dose methotrexate in children.

@article{Camitta1978SafetyOD,
  title={Safety of delayed leucovorin "rescue" following high-dose methotrexate in children.},
  author={Bruce M. Camitta and John S. Holcenberg},
  journal={Medical and pediatric oncology},
  year={1978},
  volume={5 1},
  pages={55-9}
}
High-dose methotrexate (HDMTX) with leucovorin (CF) "rescue" is being investigated for treatment of many malignant tumors. CF is usually begun 2 hours after ending the HDMTX infusion. However, since CF and methotrexate compete for the same cellular transport system, at high extracellular methotrexate concentrations it may be impossible to "rescue" cells with CF. A regimen of HDMTX with delayed leucovorin "rescue" was therefore designed. In this program, a 6-hour infusion of methotrexate (7.5 gm… CONTINUE READING