Safety of benzodiazepines in the geriatric population

@article{Madhusoodanan2004SafetyOB,
  title={Safety of benzodiazepines in the geriatric population},
  author={Subramoniam Madhusoodanan and Olivera J Bogunovic},
  journal={Expert Opinion on Drug Safety},
  year={2004},
  volume={3},
  pages={485 - 493}
}
Benzodiazepines are the most frequently prescribed antianxiety drugs in the elderly. Despite their usefulness and safety in the younger population, there is concern about the rationale for their use in the elderly. Studies of the therapeutic use of benzodiazepines in the elderly are rare. Elderly females with co-morbid medical and psychiatric conditions and who are taking multiple medications form the group most frequently prescribed benzodiazepines among the elderly, and the group most likely… Expand
The diagnosis and management of benzodiazepine dependence
  • H. Ashton
  • Medicine
  • Current opinion in psychiatry
  • 2005
TLDR
Benzodiazepine dependence could be prevented by adherence to recommendations for short-term prescribing (2–4 weeks only when possible), and withdrawal from dependent patients is feasible and need not be traumatic if judiciously, and often individually, managed. Expand
Les problèmes posés par l’utilisation des benzodiazépines chez le patient âgé
TLDR
It is obvious that it is essential to have a recourse strategy for cessation, and as much as possible to use BZD with a short half-life that are not metabolised in the strictest sense of the term, such as lorzepam or temazepam. Expand
Benzodiazepines and risk of dementia in the elderly
TLDR
Several assumptions were led to several assumptions about the putative mechanism explaining the relationship found between benzodiazepine use and dementia: (1) Benzodiazepines could be early markers of symptoms such as anxiety, depression or insomnia, which are potential prodromes or risk factors for this disease, and these drugs could also reduce the ability to use cognitive reserve in order to cope with early lesions of the disease during the preclinical stage. Expand
Inappropriate use of psychotropic drugs in older individuals: implications for practice
TLDR
The use of psychotropic drugs in older adults remains controversial given the risk of adverse effects, in contrast to the limited effectiveness, and Guidelines advise a thorough risk–benefit analysis before the initiation of psychotropics. Expand
Trends in the prescription of benzodiazepines for the elderly in Korea
TLDR
The regression analyses found that the inappropriate long-term use of benzodiazepines in the elderly was significantly related to the patients visiting several institutions and physicians prescribing more than 30 days’ worth of medication. Expand
Roles for pharmacists in improving the quality use of psychotropic medicines in residential aged care facilities
TLDR
The key objective of this thesis was to assess if pharmacists could positively influence RACF psychotropic utilisation through the use of a series of facility-focused QUM strategies delivered in a dedicated intervention project. Expand
[The addicted patient in anaesthesia - benzodiazepine dependence].
TLDR
Characteristics and complications accompanied by critical benzodiazepine use especially in the elderly patients and long-term Benzodiazepines in low-dose use are presented. Expand
Is there really a link between benzodiazepine use and the risk of dementia?
TLDR
The body of evidence seems sufficient for avoiding prescriptions or renewals that are not fully justified and indiscriminate long-term use and if the causal nature of this association remains unproved, the reviewed material provides arguments for evoking a causal link. Expand
Use of Benzodiazepines in Alzheimer’s Disease: A Systematic Review of Literature
TLDR
A relatively high prevalence of benzodiazepine use but limited evidence for clinical efficacy in Alzheimer’s disease patients is shown, however, there is a paucity of methodologically high quality controlled clinical trials. Expand
Pharmacotherapy for insomnia.
TLDR
The available efficacy data support the use of benzodiazepine receptor agonists (BzRAs), and to a lesser extent ramelteon, for the pharmacological treatment of insomnia. Expand
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 87 REFERENCES
Defining Patterns of Benzodiazepine Use in Older Adults
TLDR
A set of definitions for classification of use can be used to develop clinical guidelines based on empirically derived clinical research models and help improve identification of which patients will benefit from intermittent versus continuous treatment while minimizing risk for adverse side effects. Expand
[Benzodiazepine use in the elderly: the EVA Study].
TLDR
Benzodiazepines are the sedative and sleeping drugs most widely used by the elderly and are shown to be associated with symptoms of depression or anxiety. Expand
Practical geriatrics: Use of benzodiazepines among elderly patients.
TLDR
The literature is reviewed on the extent of benzodiazepine use and dependence among elderly persons and specific problems that arise and how to identify and treat these problems. Expand
Use of Benzodiazepines in Primary‐care Geriatric Patients
TLDR
It appears that in this age group, prolonged use of benzodiazepine at low doses, with the patients regulating the quantity, is safe and may be helpful. Expand
Benzodiazepine hypnotics in the elderly
  • P. Cook
  • Medicine
  • Acta psychiatrica Scandinavica. Supplementum
  • 1986
TLDR
Control studies in which subjects of different ages have received single doses of diazepam have consistently shown an increase in the response to benzodiazepines in the elderly which is not explained by the effects of disease or by altered plasma concentrations. Expand
Benzodiazepine dependence and withdrawal in elderly patients.
TLDR
During gradual taper of benzodiazepine doses, the elderly patients showed significantly less severe withdrawal symptoms on several clinical measures and a comparably favorable outcome. Expand
Toxicity of nitrazepam in the elderly: a report from the Boston Collaborative Drug Surveillance Program.
TLDR
It is suggested that there is little reason to exceed 5mg doses of nitrazepam for most patients, particularly those who are elderly, but the elderly are readily susceptible to excessive CNS depression at high doses. Expand
Adverse drug reactions associated with global cognitive impairment in elderly persons.
TLDR
Sedative hypnotic agents were the commonest drugs associated with cognitive impairment in patients with dementia or suspected dementia, and the number of drugs used, use of sedative hypnotics and antihypertensives, and falling were strongly associated with adverse reactions in logistic regression analyses. Expand
Long-Term Benzodiazepine Use and Cognitive Decline in the Elderly: The Epidemiology of Vascular Aging Study
TLDR
It is suggested that long-term use of benzodiazepines is risk factor of increased cognitive decline in the elderly and episodic and recurrent users had lower cognitive scores than nonusers. Expand
Medication for the Elderly
TLDR
Drug therapy in elderly patients should be kept simple and the number of drugs given simultaneously should be limited, and dosage may need to be reduced when a drug has a narrow therapeutic index or is excreted unchanged via the kidneys. Expand
...
1
2
3
4
5
...