Safety of attenuated smallpox vaccine LC16m8 in immunodeficient mice.

  title={Safety of attenuated smallpox vaccine LC16m8 in immunodeficient mice.},
  author={Hiroyuki Yokote and Yasuhiko Shinmura and Tomomi Kanehara and Shinichi Maruno and Masahiko Kuranaga and Hajime Matsui and So Hashizume},
  journal={Clinical and vaccine immunology : CVI},
  volume={21 9},
Freeze-dried live attenuated smallpox vaccine LC16m8 prepared in cell culture has been the sole smallpox vaccine licensed in Japan since 1975 and was recently recommended as a WHO stockpile vaccine. We evaluated the safety of recently remanufactured lots of LC16m8 using a series of immunodeficient mouse models. These models included suckling mice, severe combined immunodeficiency disease (SCID) mice, and wild-type mice treated with cyclosporine. LC16m8 showed extremely low virulence in each of… CONTINUE READING