Safety of antidepressants

  title={Safety of antidepressants},
  author={J. A. Swinkels and Frans de Jonghe},
  journal={International Clinical Psychopharmacology},
There are a number of criteria that can be used when selecting an antidepressant. In particular safety criteria are important, and a distinction can be drawn between “safe” and “less safe” antidepressants. The relative safety of different antidepressants has been assessed by looking at answers to the questions: how safe is the drug in overdose; how dangerous are its side effects at therapeutic dose; and does it have any dangerous interactions with other drugs or substances? Based on current… Expand
Antidepressants, old and new. A review of their adverse effects and toxicity in overdose.
  • J. Sarko
  • Medicine
  • Emergency medicine clinics of North America
  • 2000
The newer antidepressants are as efficacious as the older agents in the treatment of depression. They have a side effect profile that is different from the older drugs and are generally betterExpand
Proconvulsant effects of antidepressants — What is the current evidence?
Most antidepressants are regarded as safe and may be used in patients with epilepsy, such as the newer serotonin and/or noradrenaline reuptake inhibitors, but four older drugs should, however, be avoided or used with caution. Expand
‘Atypical’ Antidepressants in Overdose
There can be no generic response by medical practitioners as to the ‘safety’ of these new antidepressants, and the available information is reviewed in a manner intended to benefit both prescribers and clinical toxicologists. Expand
Safety of Hypericum in Patients with Depression
Although hypericum was associated with fewer and milder ADRs in clinical trials than any of the other drugs, comparisons were difficult because of the different forms in which information was presented, and data on the safety of hypericum in overdose and on interactions with other drugs are as yet scarce. Expand
Which is the safest antidepressant to use in epilepsy
There have been no double-blind trials performed to determine differences between seizure rates for two drugs or between drug and control groups, and methodological problems become apparent when comparing the results of published studies available. Expand
Position statement of the European Psychiatric Association (EPA) on the value of antidepressants in the treatment of unipolar depression
Abstract This position statement will address in an evidence-based approach some of the important issues and controversies of current drug treatment of depression such as the efficacy ofExpand
A comparison of the post-marketing safety of four selective serotonin re-uptake inhibitors including the investigation of symptoms occurring on withdrawal.
Paroxetine is the most pharmacologically specific of the SSRIs, but it is not clear whether the reactions constitute a 'serotonin withdrawal syndrome'. Expand
Antidepressants and seizures: clinical anecdotes overshadow neuroscience.
If the newer, more selective monoamine uptake blockers have very low convulsant liability, these drugs can be used safely in epileptic patients with depression, and it is possible that their anticonvulsant activity can be exploited for use in the treatment of epilepsy. Expand
Off-label uses of trazodone: a review
The possibility that a combination of trazodone with SSRIs may prevent or treat some of the SSRI side effects, such as anxiety, insomnia and sexual dysfunction, in addition to synergically increasing SSRI' antidepressant activity is discussed. Expand
Antidepressant Drugs and Seizure Susceptibility: From In Vitro Data to Clinical Practice
The available data suggest that ADs may display both convulsant and anticonvulsant effects and that the most important factor in determining the direction of a given compound in terms of excitation/inhibition is drug dosage. Expand


Pharmacological characterization of selective serotonin reuptake inhibitors (SSRIs)
  • J. Hyttel
  • Biology, Medicine
  • International clinical psychopharmacology
  • 1994
Since the marketed SSRIs all show clear antidepressant effect, this receptor regulation seems not to be a prerequisite for clinical antidepressant activity. Expand