Safety of anticonvulsants in hepatic porphyrias

@article{Reynolds1981SafetyOA,
  title={Safety of anticonvulsants in hepatic porphyrias},
  author={N. Reynolds and R. M. Miska},
  journal={Neurology},
  year={1981},
  volume={31},
  pages={480 - 480}
}
Because acute attacks of porphyria may be precipitated by anticonvulsants, a therapeutic dilemma arises when seizures complicate hepatic porphyria. The list of unsafe agents includes barbiturates, primidone, phenytoin, mephenytoin, ethotoin, ethosuximide, methsuximide, phensuximide, and trimethadione. Agents are considered unsafe if they induce experimental porphyria in animals, and short trials in patients are unreliable for screening. Using drug incubation in chick-embryo hepatocyte culture… Expand
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