Safety of antiandrogen therapy for treating prostate cancer

  title={Safety of antiandrogen therapy for treating prostate cancer},
  author={Francesco Ricci and Giulia Buzzatti and Alessandra Rubagotti and Francesco Boccardo},
  journal={Expert Opinion on Drug Safety},
  pages={1483 - 1499}
Introduction: Antiandrogens are a treatment option in patients with prostate cancer, given either in combination with androgen deprivation or, in selected cases, as monotherapy. New-generation antiandrogens have been recently introduced in clinical practice (enzalutamide) or are under evaluation in clinical trials (ARN-509). Areas covered: This review elucidates the safety profile of antiandrogens, in particular focusing on the tolerability profile of each drug either when employed in… 

Androgen receptor antagonists compromise T cell response against prostate cancer leading to early tumor relapse

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Cardiovascular toxicities of systemic treatments of prostate cancer

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Antiandrogens in the treatment of prostate cancer.

Is there a role for antiandrogen monotherapy in patients with metastatic prostate cancer?

Patients with a higher disease burden (PSA >400 ng/ml) may decide that quality of life and symptomatic benefits outweigh the slight survival disadvantage seen in clinical trials and opt for bicalutamide monotherapy as an alternative to castration.

Antiandrogen treatments in locally advanced prostate cancer: are they all the same?

  • D. Gillatt
  • Medicine, Biology
    Journal of Cancer Research and Clinical Oncology
  • 2006
The available evidence indicates that the different antiandrogens should not be regarded as equivalents in clinical practice and so the choice of treatment for patients with prostate cancer should be made on an individual basis.

Single-Therapy Androgen Suppression in Men with Advanced Prostate Cancer

It is established that DES is equivalent to orchiectomy as a comparator for treatments of advanced prostate cancer and the findings on four questions are summarized.

Antiandrogen monotherapy in the management of advanced prostate cancer.

Preliminary results suggest that bicalutamide (Casodex, Zeneca Ltd) is as effective as castration in non-metastatic disease.

Androgen Receptor Antagonists in Castration-Resistant Prostate Cancer

A review of 2 AR-targeted agents recently approved by the Food and Drug Administration and 2 direct antagonists, enzalutamide and ARN-509, that induce apoptosis without agonist activity in preclinical models shows great promise for patients with advanced disease.

Secondary hormonal therapy for advanced prostate cancer.

ARN-509: a novel antiandrogen for prostate cancer treatment.

ARS-509 exhibits characteristics predicting a higher therapeutic index with a greater potential to reach maximally efficacious doses in man than current AR antagonists, and offers preclinical proof of principle for ARN-509 as a promising therapeutic in bothCastration-sensitive and castration-resistant forms of prostate cancer.

Phase I study of ARN-509, a novel antiandrogen, in the treatment of castration-resistant prostate cancer.

  • D. RathkopfM. Morris H. Scher
  • Medicine, Biology
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • 2013
ARN-509 was safe and well tolerated, displayed dose-proportional pharmacokinetics, and demonstrated pharmacodynamic and antitumor activity across all dose levels tested.