Safety of and immunological response to a recombinant vaccinia virus vaccine expressing HIV envelope glycoprotein.

@article{Cooney1991SafetyOA,
  title={Safety of and immunological response to a recombinant vaccinia virus vaccine expressing HIV envelope glycoprotein.},
  author={E L Cooney and Ann C Collier and Philip D. Greenberg and Robert W. Coombs and Joyce Zarling and D E Arditti and Mary C Hoffman and Shiu Lok Hu and Lawrence Corey},
  journal={Lancet},
  year={1991},
  volume={337 8741},
  pages={567-72}
}
In a randomised phase I trial of a recombinant vaccina virus vaccine expressing the gp160 envelope gene of the human immunodeficiency virus (HIVAC-1e) 35 healthy, HIV-seronegative males, 31 of whom had a history of smallpox immunisation and 4 of whom were vaccinia naive, were vaccinated and then boosted 8 weeks later with HIVAC-1e or standard NY strain vaccinia virus. The frequency, duration, and titre of virus isolation from the vaccination site and occurrence of local side-effects were… CONTINUE READING

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