Safety of a universal, virus-inactivated and prion-depleted, pharmaceutical-quality plasma: a randomized, double-blind, clinical trial in healthy volunteers.

@article{JilmaStohlawetz2011SafetyOA,
  title={Safety of a universal, virus-inactivated and prion-depleted, pharmaceutical-quality plasma: a randomized, double-blind, clinical trial in healthy volunteers.},
  author={Petra Jilma-Stohlawetz and Friedrich W Kursten and Claudia Walasek and Michaela Horvath and Gerda Leitner and Jana List and Peter Quehenberger and Michael Schwameis and Johann Bartko and Bernd Jilma},
  journal={Transfusion},
  year={2011},
  volume={51 6},
  pages={1228-40}
}
BACKGROUND Universal plasma is intended to be transfused irrespective of the blood group. We compared the safety and tolerability of a novel, universal blood group-independent plasma with an ABO-matched plasma. STUDY DESIGN AND METHODS In this randomized, double-blind, active-controlled, crossover, Phase I trial, 30 healthy adult volunteers (blood group A, B, or AB) were randomly assigned to transfusion of 1200 mL of Uniplas LG and 1200 mL of Octaplas LG (both Octapharma AG) or vice versa. In… CONTINUE READING