Safety of a novel galacto-oligosaccharide: Genotoxicity and repeated oral dose studies.

@article{Kobayashi2009SafetyOA,
  title={Safety of a novel galacto-oligosaccharide: Genotoxicity and repeated oral dose studies.},
  author={Toshihide Kobayashi and Nobuyoshi Yasutake and Keiko Uchida and Wakako Ohyama and Kimiyuki Kaneko and Masaharu Onoue},
  journal={Human & experimental toxicology},
  year={2009},
  volume={28 10},
  pages={
          619-30
        }
}
A series of safety tests were undertaken on a novel galacto-oligosaccharide (GOS) produced from lactose by a two-step enzymatic process involving Sporobolomyces singularis and Kluyveromyces lactis. Bacterial reverse mutation and chromosomal aberration tests, with or without metabolic activation, were performed. These tests showed no mutagenesis in the Ames assay or in Escherichia coli WP2uvrA, and no chromosomal aberrations in cultured fibroblast cells from Chinese hamster lungs (CHL/IU… CONTINUE READING
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