Safety of a New Oral Contraceptive Containing Drospirenone
@article{Heinemann2004SafetyOA, title={Safety of a New Oral Contraceptive Containing Drospirenone}, author={Lothar A. J. Heinemann and J{\"u}rgen C Dinger}, journal={Drug Safety}, year={2004}, volume={27}, pages={1001-1018} }
New chemical entities must undergo rigorous, and preferably independent, safety and efficacy assessments before entry into the market. This is also true for oral contraceptives (OCs) given their extensive usage by healthy women and the safety concerns highlighted by the so-called ‘third generation pill scare’ in Europe a decade ago. This scare heightened patient and physician awareness of the increased risk of thromboembolic complications (mainly venous thromboembolism [VTE]) associated with OC…
41 Citations
The safety of a drospirenone-containing oral contraceptive: final results from the European Active Surveillance Study on oral contraceptives based on 142,475 women-years of observation.
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Clinical experiences with drospirenone: from reproductive to postmenopausal years.
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The association between drospirenone and hyperkalemia: a comparative-safety study
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Despite the bolded warning for hyperkalemia with joint drospirenone and spironolactone administration, physicians are actually using them together preferentially, and are not following the recommended potassium monitoring requirements in the package insert.
Irritable bowel syndrome and drospirenone-containing oral contraceptives; a comparative-safety study.
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A positive association between drospirenone and a diagnosis of IBS that was not observed with other OCs was found, and multiple sensitivity analyses confirmed this association.
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Use of oral contraceptives containing gestodene and risk of venous thromboembolism: outlook 10 years after the third-generation "pill scare".
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Combined hormonal contraception and venous thromboembolism
- Medicine, BiologyThe European journal of contraception & reproductive health care : the official journal of the European Society of Contraception
- 2007
The greatest risk of COC-associated VTE occurs during the first year of use, thus suggesting the existence of a predisposing condition, such as being a carrier of a thrombogenic mutation with which the COCs would exert a synergistic effect.
Arterial thrombosis and drospirenone-containing pill (Yasmin). Is the pill to be absolutely avoided by women who smoke?
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It seems safe to underscore that smokers even moderate ones should abstain from OC intake or vice versa should stop smoking while on the medication, especially so for drospirenone-containing preparations.
Risk of Thromboembolism in Women Taking Ethinylestradiol/Drospirenone and Other Oral Contraceptives
- MedicineObstetrics and gynecology
- 2007
Ethinylestradiol/drospirenone initiators and initiators of other oral contraceptives are similarly likely to experience thromboembolism.
Rate of Pregnancy After Using Drospirenone and Other Progestin-Containing Oral Contraceptives
- MedicineObstetrics and gynecology
- 2009
Previous oral-contraceptive use does not negatively affect initial and 1-year rates of pregnancy after oral- Contraceptive cessation, and a comparison of these data with data external to this study indicates that the negative effect of aging on fecundity is not amplified by oral-contained use.
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