Safety of Perioperative Aprotinin Administration During Isolated Coronary Artery Bypass Graft Surgery: Insights From the ART (Arterial Revascularization Trial)

@article{Benedetto2018SafetyOP,
  title={Safety of Perioperative Aprotinin Administration During Isolated Coronary Artery Bypass Graft Surgery: Insights From the ART (Arterial Revascularization Trial)},
  author={U. Benedetto and D. Altman and Stephen Gerry and A. Gray and B. Lees and G. Angelini and M. Flather and D. Taggart and C. S. J. C. S. M. K. A. R. D. P. M. R. R. T. W. J. V. Ratnatunga Westaby Cook Wallis Wos Jasinski Widenk and C. Ratnatunga and S. Westaby and J. Cook and C. Wallis and S. Woś and M. Jasiński and K. Widenka and A. Błach and R. Gocoł and D. Hudziak and P. Žůrek and M. Deja and R. Bachowski and R. Mrozek and T. Kargul and W. Domarardzki and J. Frackiewicz and V. Zamvar and D. Ezakadan and B. Buxton and S. Seevanayagam and G. Matalanis and A. Rosalion and J. Negri and S. Moten and V. Atkinson and A. Newcomb and P. Polidano and R. Pana and S. Gerbo and P. O'Keefe and U. V. von Oppell and D. Mehta and A. Azzu and A. Szafranek and E. Kulatilake and J. Evans and N. Martin and D. Banner and U. Trivedi and A. Forsyth and J. Hyde and A. Cohen and M. Lewis and E. Gardner and A. Mackenzie and N. Cooter and E. Joyce and J. Parker and F. Champney and S. Clark and J. Dark and K. Tocewicz and T. Pillay and S. Rowling and J. Adams‐Hall and A. Bochenek and M. Cisowski and M. Bolkowski and W. Morawski and M. Guc and M. Krejca and M. Wilczyński and A. Durałek and W. Gerber and J. Skarysz and R. Shrestha and W. Święch and P. Szmagała and L. Krzych and A. Pawlak and K. Kępa and R. Hasan and D. Keenan and B. Prendergast and N. Odom and K. McLaughlin and G. Cummings‐Fosong and C. Mathew and H. Iles-Smith and A. Oomen and J. Desai and A. El-Gamel and L. John and O. Wendler and M. Andrews and K. Rance and R. Williams and V. Hogervorst and J. Gregory and J. Jessup and A. Knighton and A. Hoare and A. Ritchie and C. Choong and S. Nair and D. Jenkins and S. Large and C. Sudarshan and M. Barman and K. Dhital and T. Routledge and B. Rosengard and H. Munday and K. Rintoul and E. Jarrett and S. Lao-Sirieix and A. Wilkinson and L. Garner and J. Osmond and H. Holcombe and A. Cale and S. Griffin and J. Dickson and T. Spyt and M. Hickey and A. Sosnowski and G. Peek and J. Szostek and L. Hadjinikalaou and E. Logtens and M. Oakley and S. Leji and J. Gaer and M. Amrani and G. Dreyfus and T. Bahrami and F. de Robertis and K. Baig and G. Asimakopoulos and H. Vohra and V. Pai and S. Tadjkarimi and B. Soleimani and G. Stavri and G. Bull and H. Collappen and J. Sadowksi and B. Gaweda and P. Rudziński and J. Stoliński and J. Konstanty-Kalandyk and F. Moraes and C. Moraes and J. Wanderley and J. Pepper and A. de Souza and M. Petrou and R. Trimlett and T. Morgan and J. Gavino and S. Wang and V. Chandrasekaran and R. Kanagasaby and M. Sarsam and H. Ryan and L. Billings and L. Ruddick and A. Achampong and E. Forster and R. Pawlaczyk and P. Siondalski and J. Rogowski and K. Roszak and K. Jarmoszewicz and D. Jagielak and S. Gafka and G. Mannam and G. Naguboyin and L. Rao Sajja and B. Dandu and N. Briffa and P. Braidley and G. Cooper and K. Allen and G. Sangha and C. Bridge and H. McMellon and R. Casabona and G. Actis Dato and G. Bardi and S. Del Ponte and P. Forsennati and F. Parisi and G. Punta and R. Flocco and F. Sansone and E. Zingarelli and W. Dihmis and M. Kuduvali and C. Prince and H. Rogers and L. McQuade and L. Anisimowicz and M. Bokszanski and W. Pawliszak and J. Kołakowski and G. Lau and W. Ogorzeja and I. Gumanska and P. Kulinski and B. Podesser and K. Trescher and O. Bernecker and C. Holzinger and K. Binder and I. Schor and P. Bergmann and H. Kassal and B. Motovova and N. Trehan and Z. Meharwal and R. Malhotra and M. Goel and B. Kumer and S. Bazaz and N. Bake and A. Singh and Y. Mishka and R. Gupta and S. Basumatary and M. Zembala and B. Szafron and J. Pacholewicz and M. Krasoń and A. Farmas and J. Wojarski and B. Zych and I. Szymanik and M. Kolwca and W. Mazur and A. Kurowicki and S. Zurek and T. Stącel and I. Jaworska and P. Sleight and K. Channon and B. Farrell and R. Stables and G. Vermes and J. Pearson and M. Pitman and S. Yusuf and S. Pocock and D. Julian and T. Treasure and U. Von Oppel and R. Kanagasabay and J. Collinson and A. Bakhai and R. O'Hanlon and D. Kotecha and K. Qureshi and T. Geisler and L. Manzano-Espinosa},
  journal={Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease},
  year={2018},
  volume={7}
}
  • U. Benedetto, D. Altman, +261 authors L. Manzano-Espinosa
  • Published 2018
  • Medicine
  • Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
  • Background There is still uncertainty about the safety of aprotinin for coronary artery bypass graft surgery. The ART (Arterial Revascularization Trial) was designed to compare survival after bilateral versus single internal thoracic artery grafting. Many of the ART patients (≈30%) received perioperative aprotinin. We investigated the association between perioperative aprotinin administration and short‐term (in‐hospital) and long‐term outcomes by performing a post hoc analysis of the ART… CONTINUE READING
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    References

    SHOWING 1-10 OF 23 REFERENCES
    The effect of aprotinin on outcome after coronary-artery bypass grafting.
    • 191
    Aprotinin during coronary-artery bypass grafting and risk of death.
    • 204
    Mortality associated with aprotinin during 5 years following coronary artery bypass graft surgery.
    • 370
    • PDF
    The risk associated with aprotinin in cardiac surgery.
    • 1,060
    Aprotinin Does Not Increase the Risk of Renal Failure in Cardiac Surgery Patients
    • 86
    A comparison of aprotinin and lysine analogues in high-risk cardiac surgery.
    • 965
    • PDF
    Randomized Trial of Bilateral versus Single Internal-Thoracic-Artery Grafts.
    • 244
    • PDF
    Effect of peri-operative red blood cell transfusion on 30-day and 1-year mortality following coronary artery bypass surgery.
    • M. Kuduvalli, A. Oo, +5 authors A. Rashid
    • Medicine
    • European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery
    • 2005
    • 250
    • PDF