Safety of Low Doses of Quetiapine When Used for Insomnia

@article{Coe2012SafetyOL,
  title={Safety of Low Doses of Quetiapine When Used for Insomnia},
  author={Holly V Coe and I. Hong},
  journal={Annals of Pharmacotherapy},
  year={2012},
  volume={46},
  pages={718 - 722}
}
Objective: To evaluate the safety of low doses of quetiapine when used for insomnia. Data Sources: A literature search was performed using PubMed and EMBASE (January 1990-November 2011) using the terms quetiapine, insomnia, sleep, low-dose, subtherapeutic, safety, and weight gain. Study Selection And Data Extraction:: Two prospective trials were identified that evaluated the effect of quetiapine in primary insomnia. In addition, 2 retrospective cohort studies were identified that evaluated the… Expand
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Current data do not appear to support quetiapine's use as first-line treatment for sleep complications, however, it may be useful for treatment of insomnia in patients with psychiatric disorders who do not respond to primary or secondary treatments. Expand
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Despite the low doses typically used when quetiapine is prescribed for insomnia, metabolic adverse effects can occur and should be considered in the overall benefit to risk analysis. Expand
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The results suggest that there is extensive use of expensive atypical antipsychotic medications for off-label purposes such as sedation or for other practice patterns that should be explored further. Expand
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