Safety of Long-Term Bisphosphonate Therapy for the Management of Osteoporosis

@article{Lewiecki2011SafetyOL,
  title={Safety of Long-Term Bisphosphonate Therapy for the Management of Osteoporosis},
  author={Dr E. Michael Lewiecki},
  journal={Drugs},
  year={2011},
  volume={71},
  pages={791-814}
}
Drugs in the bisphosphonate class are the most commonly prescribed therapeutic agents for the treatment of osteoporosis. Prospective, randomized, placebo-controlled clinical trials have demonstrated efficacy in reducing fracture risk, with favourable safety profiles, in women with postmenopausal osteoporosis. However, long-term use in clinical practice has been associated with reports of undesirable events not previously recognized. These have included gastrointestinal intolerance… CONTINUE READING
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